KURCHII, BOGDAN. Plant Physiology Institute and Genetics, Vasylkivska 31/17, 03022 Kiev, Ukraine. - A little bad fact can kill a very attractive and nice ethylene receptor theory.
Ethylene as plant growth regulator attracts an attention of many
biologists. However, exactly what this molecule does in the cells is
not clear. Its biological effects were explained by the formation of
ethylene-receptor (ethylene-proteins) complexes onto the living cells.
But what is the nature of a bond of such sophistical ethylene-receptor
complex? Perhaps, one of the most delightful characteristics of theory
of biological receptors is that just when we things we know all about
this phenomena, a forgotten fact come along that exposes our state of
ignorance. It is very known that ethylene at normal (ordinary)
temperature and pressure is a very inert chemical. It cannot enter
neither addition nor abstraction reactions. This is a fundamental
chemical law and a bad (unpleasant) fact for biologists. Thus, the big
question will remain: What is the chemical logic for so small molecule
as ethylene to conjugate with so large molecules as proteins or
peptides and then try to pass through so small membraneous pore to
activate mostly putative enzymes? Many biological effects caused by
chemical agents including ethylene are similar to those caused by
exposure of plants to physical factors. Next question is: Such
physical factors as X-ray, electrical or magnetic fields also require
the conjugation with receptors to cause biological effects? Our data
suggest that biological effects of ethylene are caused by formation of
its free radicals in the free radical addition reactions of endogenous
free radicals to an unsaturated bond. Free radicals of ethylene are
reactive agents (they do not require any receptors) and can oxide many
biological molecules, first of all membraneous lipids, also they can
bind to many substances and thus it forms so called ethylene-receptor
complexes. These bonded chemically non-active structures are
consequences (not causes) of the free radical activation and action of
ethylene.
Key words: ethylene, free radicals, receptors