Arisaema (Araceae) has an unusually widespread, temperate distribution including eastern Africa, Asia, and North America. It has consistent basic morphological features, but a high diversity in its specific modifications on various structures (e.g., shape and coloration of the spathe and appendix, paradioecy, leaf divisions, tuber shape etc.). This suggests recent speciation, and obscures species delimitations and homologies. For this phylogenetic analysis, 42 taxa were sampled (incl. Pinellia, Arisarum and Biarum), represented by a total of 74 DNA sequences of ITS1, ITS2, and the 5.8S region of the nuclear rRNA genes. Amplification with primers specific for the ITS region of plants turned out to be difficult. By modifying the protocols, cloning and trying different accessions of the same species, potential problems were evaluated, such as degeneration of DNA, inhibition by secondary compounds or polysaccharides, and effects caused by secondary structure. Only the use of less specific primers resulted in good PCR yields. This implies that the polymerase is not inhibited, but rather that the primer binding site may be inaccessible for specific primers due to strong, species-specific secondary structures (or proteins). The sequences obtained represent paralogs that are difficult to align; hence, relationships could not be resolved. The activity of the paralogs could not be determined. Possible ways to overcome this primer-binding problem, to select active or homologous ITS sequences, and the potential of ITS-paralogs for the study of recent speciation are discussed.

Key words: Arisaema Araceae ITS Secondary Structure