With the recent disintegration of Scrophulariaceae and re-circumscription of Plantaginaceae based on molecular data, the genus Veronica, sister to Plantago in numerous molecular analyses, has shifted to the center of interest, because of several similarities with Plantago, especially the tetramerous flower. Analyses of DNA sequence data (ITS and trnL-F) allows us not only to point out trends in Plantago and Veronica that originate in their common ancestor but also to elucidate different Veronica-specific evolutionary trends of reductions in various characters. These reductions include general habit, flower morphology, chromosome number and genome size. These reductions appear most extreme in the annual species of Veronica, which for a long time have been considered a natural group because of parallel evolution leading to an "annual syndrome". Whereas it seems that this syndrome also includes high molecular evolutionary rate and low genome size, this may rather be associated with the breeding system, which is tightly but not completely associated with life-form.

Key words: evolutionary trends, flower evolution, genome size, Lamiales, molecular phylogeny, Veronica