The classification of the Amaranthaceae s.s. has divided the family into two distinct subfamilies, the Amaranthoideae and Gomphrenoideae. Recent evidence has supported the segregation of a monophyletic Gomphrenoideae as a group of 20 genera centered in the New World tropics segregated from the Amaranthoideae principally on the presence of 1-locular as opposed to the 2-locular anthers in the Amaranthoideae. Relationships within the subfamily have been complicated through varying interpretations of floral fusion and a strong reliance on stigma architecture. To analyze phylogenetic relationships within the subfamily, a morphological dataset was constructed using macro- and micromorphological characters for each of the 20 genera. Parsimony analysis showed that the Gomphrenoideae do form a monophyletic lineage, and suggested that the group consists of two principal clades, a Gomphrenoid clade and a Pfaffioid clade. Further inference into phylogeny was gained through molecular analyses performed on 27 taxa in 10 of the principal genera of the Gomphrenoideae using sequences of the internal transcribed spacer 1 of nuclear ribosomal DNA (nrITS1). Molecular analyses support the monophyly of the group and provide additional support for two major clades within the subfamily. Most genera are shown to form monophyletic lineages, including the large genera Alternanthera and Iresine. The genus Gomphrena is shown to be polyphyletic with some species forming a true Gomphrena clade (G. globosa, G. sonorae, etc.) with the others distributed within the large Gomphrenoid clade (G. boliviana) or in close association with the genus Pfaffia (G. mandonii). The anomalous genus Pseudoplantago is shown to occur within the Pfaffiod clade of the Gomphrenoideae, despite a number of morphological characters that have suggested a transfer to the subfamily Amaranthoideae. The arid North American genus Tidestromia, exhibiting a unique floral and pollen morphology, is shown to fall basal to the principal groups of the Gomphrenoideae.

Key words: Amaranthaceae, its1, phylogeny