Regulatory genes represent a class of loci that control the expression of other genes. It is well-known that regulatory gene evolution is a significant factor in organismal diversification. Thus, the studies of regulatory gene evolution in plant may provide clues on the morphological differentiation and ecological adaptation. Plants display remarkable diversity in the pattern and intensity of red or purple anthocyanin pigmentation in vegetative and floral organs. Mutations that stop anthocyanin production can be controlled by regulators of the biosynthetic genes, which occur as a gene family in the diverse plant species. Morphological analysis of the dwarf dogwood species complex (Cornus subgen. Arctocrania) suggested extensive hybridization occurred between two evolutionary diverged species (C. canadensis and C. suecica), which may have led to the formation of two hybrid lineages (C. canadensis>C. suecica, and C. suecica>C. canadensis) and one allo-tetraploid species (C. unalaschkensis). The five taxa in the complex exhibit variation in the color of petals, which provides an excellent system to study molecular evolution and speciation following hybridization and polyploidization using flower pigmentation regulatory genes. We investigate the homologs of R gene family which regulates the red anthocyanin pigmentation in plants. A portion of 750bp of this gene in the exon 1, 2 and intron 1 regions has been amplified, cloned and sequenced for samples representing different putative taxa. Two types of sequences (referred to as “a” and “b”) were identified, which have alignable exon regions, but are highly divergent in the intron region. There are sequence variations in both exon and intron regions in both “a” and “b” types among different populations sequenced. This preliminary data suggested that anthocyanin regulatory gene is a potential marker to study the gene evolution following hybridization and polyploidization in plants. The pattern of sequence variation and its correlation with petal color will be discussed.

Key words: Anthocyanin regulatory gene, Cornus, Dwarf dogwoods, Gene evolution, Hybridization, Polyploidization