Although the majority of genera in Gesneriaceae have bilaterally symmetric flowers, three genera in tribes Gloxinieae and Gesnerieae differ in their floral symmetry. Bellonia has a radially symmetric flower. Phinaea and Niphaea have subradially symmetric corollas. Although both Phinaea and Niphaea have only four functional stamens, typical for most of the family, Bellonia has five. The gene CYCLOIDEA (CYC) has been shown to be required for bilateral floral symmetry in Antirrhinum and Linaria. The role of CYC in the control of floral symmetry in other genera and its potential for phylogenetic reconstruction have not been widely explored. Recent work on subfamily Cyrtandroideae of Gesneriaceae has revealed a CYC homolog named GCYC. We developed primers to GCYC and used it to amplify homologs from a number of species of Gloxinieae and Gesnerieae. Sequences are readily alignable and show less variability than found in subfamily Cyrtandroideae. There is no evidence for frame shift or stop codon mutations, implying that gene function is maintained across all taxa regardless of floral symmetry. Parsimony and maximum likelihood analysis of GCYC are strongly incongruent with previous analyses of relationships among genera of these tribes. To see if the problem is with GCYC or with previous analyses sequences for a matched set of taxa were obtained for two chloroplast regions, the trnL-trnF spacer and trnL intron, and two nuclear markers, the nuclear ribosomal ITS region and the glutamine synthetase gene (GS). Two copies of GS were recovered for these tribes resulting in five genes analyzed in conjunction with the previously published ndhF sequences. These six genes are congruent with one another but not with GCYC. The six gene phylogeny presumably reflects the evolutionary history of the species and provides a robust framework for understanding the evolution of floral form and GCYC sequence evolution.

Key words: CYCLOIDEA, floral symmetry, GCYC, Gesneriaceae, Gesnerioideae